The 6 Best Mexican Restaurants in Greenville, SC

Greenville, South Carolina is known for its charming downtown, thriving arts scene, and exceptional quality of life. But for food lovers, one of the city’s best-kept secrets is its diverse and delicious culinary offerings. Among the many standout cuisines, Mexican food holds a special place in the hearts (and stomachs) of residents and visitors alike.

From authentic taquerias to modern Mexican fusion spots, Greenville offers a vibrant selection of eateries that deliver bold flavors and warm, welcoming atmospheres. These restaurants not only contribute to the city’s cultural richness but also make it an appealing destination for anyone considering homes for sale in Greenville, SC.

Nestled along the Reedy River in downtown Greenville, Papi's Tacos is a local gem that prides itself on serving simple, authentic Mexican food with heart. Started by a father-son duo, the restaurant has built a loyal following thanks to its homemade tortillas, perfectly seasoned meats, and mouthwatering salsas. Papi’s is known for its friendly service and intimate setting, often filled with the buzz of conversation and the scent of sizzling al pastor.

Favorites include their carnitas tacos, barbacoa burritos, and fresh guacamole served with warm chips. With its casual vibe and riverside location, Papi’s is an excellent stop for a quick lunch or a laid-back evening meal while exploring the heart of downtown Greenville.

For those in search of a more low-key, neighborhood-style eatery, El Tejano Mexican Restaurant fits the bill. Located slightly off the beaten path in Simpsonville, this spot offers traditional dishes served in generous portions. It’s not uncommon to find locals gathering here after work or on weekends to enjoy plates of sizzling fajitas, cheesy enchiladas, or flavorful chiles rellenos.

El Tejano's unassuming charm and consistent quality have earned it a reputation as one of Greenville’s best-kept secrets. For residents seeking a go-to spot with no-frills dining and hearty, satisfying food, this restaurant is a top contender.

Situated in the heart of downtown, Cantina 76 combines the vibrancy of a taqueria with the ambiance of a modern bar. The atmosphere is lively and stylish, drawing in crowds for both lunch and late-night bites. While it maintains the essence of traditional Mexican cuisine, the menu leans into innovation with dishes like fried chicken tacos, smoked brisket nachos, and jalapeño-infused cocktails.

The sleek bar and shaded outdoor seating area make Cantina 76 an ideal location for socializing. This restaurant is especially popular among young professionals and new residents who are exploring Greenville’s dynamic food and nightlife scene. Its creative spin on classic flavors adds a fresh dimension to the city’s culinary landscape, which continues to grow alongside its real estate market.

Tipsy Taco has become a beloved brand in the Upstate thanks to its multiple locations, fun atmosphere, and bold flavors. Whether visiting the Pelham Road location or the bustling downtown outpost, guests can expect a wide range of inventive taco creations—from Korean BBQ to Baja shrimp.

Each location offers a slightly different experience, but all share a commitment to flavorful food, colorful décor, and a welcoming vibe. With regular drink specials, a variety of salsas, and gluten-free options, Tipsy Taco caters to diverse tastes and dietary needs. For families, groups of friends, or couples on a casual date, it’s a festive and consistent choice.

La Parrilla stands out as a go-to spot for families and large groups looking for quality Mexican food in a relaxed setting. This regional chain has a strong following in the Southeast, and its Greenville location maintains the high standards that have earned it a loyal customer base.

The menu features everything from chimichangas to sizzling steak fajitas, all prepared with fresh ingredients and served with a smile. The spacious dining room and attentive staff create a welcoming environment that’s perfect for both weeknight dinners and special celebrations. Its popularity among locals highlights the community’s appreciation for flavorful food and reliable service—qualities that echo throughout the city’s neighborhoods and homes for sale in Greenville, SC.

A relative newcomer to the Greenville food scene, Comal 864 is quickly making a name for itself with an emphasis on modern Mexican cuisine and locally sourced ingredients. The restaurant’s aesthetic is sleek and contemporary, and the menu reflects a deep respect for Mexican culinary traditions with a progressive twist.

Dishes like duck confit tacos, roasted corn esquites, and house-crafted cocktails showcase the chef’s creativity and commitment to flavor. The dining experience at Comal 864 feels both elevated and accessible, making it a perfect spot for a special night out or a celebratory dinner.

The vibrant and varied Mexican dining scene in Greenville speaks to the city's diversity and culinary evolution. These restaurants contribute to the area's cultural richness, offering residents and visitors a taste of authentic and inspired cuisine. For prospective homeowners, access to excellent dining options can be a meaningful factor when choosing where to settle down. The quality of local amenities, including restaurants, is a reflection of community vitality and livability.

As interest continues to grow in homes for sale in Greenville, SC, these standout eateries are part of what makes the city such an appealing place to call home. From casual taco trucks to stylish downtown spots, Greenville offers a Mexican dining experience to suit every palate and occasion.

For guidance on making the move to this vibrant city and finding a home near your favorite restaurant, reach out to Kirsten Dinkins today. Her expertise and local insight will help you discover the best of Greenville, both on the plate and in the property market.